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15Best Drugstore Retinol Creams and Serums (Tested and Reviewed for 2023) Olay's Regenerist Retinol 24 Night Serum, CeraVe's Skin Renewing Day Cream, and Differin Gel are just a few of our top Theproducts can be purchased separately ( Retinol: $78; Milk: $50) or as a set ($120). Advertisement. In addition to the symbiosis of the two products, the application protocol is essential forRetinoicacid is normally hydrophobic, with minimal penetration through the stratum corneum layer of the epidermis. As the retinoic acid is trapped in the stratum corneum, it gradually induces irritation and inflammation associated with retinoid dermatitis. Retinoic acid is formulated in a cream (0.025%, 0.05%, 0.1%); gel (0.01%, 0.25%